abstract：:Osteosarcoma is the most common neoplasm of bone in children and adolescents. The first effective therapy became available in the early 1970s, and although controversy existed for several years regarding the relative value of aggressive multiagent chemotherapy, presently about 60% of patients with resectable primary t...

journal_title：Pediatric clinics of North America

authors： Meyer WH,Malawer MM

更新日期：1991-04-01 00:00:00

abstract：:Lymphocytic interstitial pneumonia is at present a pathologic diagnosis. In the setting of a chronic interstitial pneumonia in a child with lymphocytosis, hyperglobulinemia, and lymphadenopathy or parotid enlargement, the diagnosis is often clinically presumed. At present the diagnosis can be established firmly only b...

journal_title：Pediatric clinics of North America

authors： Pitt J

更新日期：1991-02-01 00:00:00

abstract：:CAD results from atherosclerosis, a chronic disease process that has its origin in childhood. Children and adolescents can be at higher risk for CAD by virtue of being from families with premature CAD or familial dyslipoproteinemias. The plasma lipid and lipoprotein levels result from a number of complex metabolic pro...

journal_title：Pediatric clinics of North America

authors： Kwiterovich PO Jr

更新日期：1990-12-01 00:00:00

abstract：:Hyperthyroidism in infants and children usually is caused by Graves' disease; however, several other diseases can also produce hyperthyroidism in these age groups. Because the pathophysiology and clinical course of these conditions differ, optimal treatment depends on precise diagnosis. ...

journal_title：Pediatric clinics of North America

authors： Zimmerman D,Gan-Gaisano M

更新日期：1990-12-01 00:00:00

abstract：:Although overt anemia is uncommon, depletion of body iron stores is common among adolescent female athletes. Poor dietary iron intake, menstruation, and increased iron losses associated with physical training all appear to be important factors. Whether nonanemic iron deficiency can impair exercise performance is uncer...

journal_title：Pediatric clinics of North America

authors： Rowland TW

更新日期：1990-10-01 00:00:00

abstract：:At least 1 in 10 children in the United States is born into a chemically dependent family. Parental addiction has long-lasting detrimental effects on the health and safety of children. We must mobilize to free children from the double jeopardy of substance abuse and child abuse, and interrupt the multigenerational pat...

journal_title：Pediatric clinics of North America

authors： Bays J

更新日期：1990-08-01 00:00:00

abstract：:Recently, great progress has been made in the development of vaccines against Hib. Four polysaccharide-protein conjugate vaccines are actively being tested. Three of these (PRP-D, HbOC, and PRP-OMP) are currently licensed for use in children at 15-18 months of age. Clinical trials of these vaccines in infants are curr...

journal_title：Pediatric clinics of North America

authors： Shapiro ED

更新日期：1990-06-01 00:00:00

abstract：:Despite many advances in the overall treatment of type I diabetes mellitus during the last few years, no major advance has been made in decreasing the mortality rate of diabetic ketoacidosis or hyperosmolar hyperglycemic nonketotic coma. A major concern in both of these disease states is the development of cerebral ed...

journal_title：Pediatric clinics of North America

authors： Ellis EN

更新日期：1990-04-01 00:00:00

abstract：:Derangements of fluid, electrolyte, and acid-base homeostasis are an inevitable part of acute renal failure. Understanding the pathophysiology of these disorders is essential to treating and preventing potentially life-threatening complications. Appropriate nutritional support is also an important part of management i...

journal_title：Pediatric clinics of North America

authors： Feld LG,Cachero S,Springate JE

更新日期：1990-04-01 00:00:00

abstract：:Catheter therapy has gained an important role in the treatment of congenital heart disease. The cumulative experience with vascular and valvular balloon dilations has demonstrated low mortality and morbidity with short-term results similar to surgery. Currently, balloon dilation is an accepted treatment for valvular p...

journal_title：Pediatric clinics of North America

authors： Radtke W,Lock J

更新日期：1990-02-01 00:00:00

abstract：:Modern assessment of the tonsils and adenoids is based on an appreciation of new concepts pertaining to the pathogenesis of tonsil and adenoid disease. Recognition of the emergence of beta-lactamase-producing and encapsulated anaerobic bacteria in the tonsils and adenoids should lead to a reconsideration of present th...

journal_title：Pediatric clinics of North America

authors： Brodsky L

更新日期：1989-12-01 00:00:00

abstract：:Caustic ingestions, both accidental and intentional, continue to cause significant morbidity and mortality. This article recommends the best methods of managing caustic ingestion and the related problems of foreign bodies in the digestive tracts of small children, and also stresses the need for prevention as the best ...

journal_title：Pediatric clinics of North America

authors： Friedman EM

更新日期：1989-12-01 00:00:00

abstract：:Diuretics are used in various conditions with fluid overload. Their efficacy in the management of congestive heart failure is well documented. In contrast, the indication of diuretics in chronic lung disease and central nervous system disorders of the newborn have not been clearly established. Substantial pharmacologi...

journal_title：Pediatric clinics of North America

authors： Chemtob S,Kaplan BS,Sherbotie JR,Aranda JV

更新日期：1989-10-01 00:00:00

abstract：:Beginning with a brief description of mature anatomic pathways and neurotransmitters in the "pain system," this article details their development in the human fetus, neonate, and child. Special emphasis is given to the basic mechanisms and physiologic effects of opioid analgesia. The clinical implications of these dat...

journal_title：Pediatric clinics of North America

authors： Anand KJ,Carr DB

更新日期：1989-08-01 00:00:00

abstract：:It is clear that previously we were ill-informed and misinformed about children's pain. Recent investigations have led not only to a burgeoning of understanding of pediatric pain, but also an increase in our ability to appropriately measure and treat children's pain. Both pharmaceutical and nonpharmaceutical treatment...

journal_title：Pediatric clinics of North America

authors： McGrath PJ,Craig KD

更新日期：1989-08-01 00:00:00

abstract：:The United States must improve its efforts to reduce teen pregnancy. We occupy an alarming position in the developed world from the standpoint of the magnitude of the pregnancy issue. While our society promotes sexuality to sell all sorts of consumer goods, it still refuses for the most part to make contraceptives fam...

journal_title：Pediatric clinics of North America

authors： Davis S

更新日期：1989-06-01 00:00:00

abstract：:Five issues are discussed with respect to the diagnosis, etiology, treatment, prognosis, and pathogenesis of neonatal seizures. The presentation of a newborn with seizures represents a true emergency and frequently indicates significant neurologic dysfunction or damage to the immature nervous system. Despite the urgen...

journal_title：Pediatric clinics of North America

authors： Scher MS,Painter MJ

更新日期：1989-04-01 00:00:00

abstract：:The increase in single-parent families, step-families, maternal employment, and young children in substitute care are among several important changes in the American family in recent decades. Although it is not clear that these changes necessarily lead to negative outcomes in children, it is apparent that a variety of...

journal_title：Pediatric clinics of North America

authors： Dubowitz H,Newberger CM,Melnicoe LH,Newberger EH

更新日期：1988-12-01 00:00:00

abstract：:Table 4 briefly summarizes the relative advantages and disadvantages of skin tests versus in vitro tests for detecting allergen-specific IgE. The skin test remains unexcelled as a sensitive and cost efficient test for specific IgE. The high degree of skin test sensitivity is very important when a patient must be evalu...

journal_title：Pediatric clinics of North America

authors： Ownby DR

更新日期：1988-10-01 00:00:00

abstract：:In summary, wheezing is a common manifestation of viral respiratory tract disease in infancy. The precise pathogenetic mechanisms of virus-induced wheezing and its sequelae are not clear, although recent reports about participation of the cellular and humoral immune systems are promising. Although therapies like those...

journal_title：Pediatric clinics of North America

authors： Skoner D,Caliguiri L

更新日期：1988-10-01 00:00:00

abstract：:In this article we reviewed some of the important concepts and techniques of molecular biology applied to the study of lymphoid malignancies. Molecular biology is a tool for addressing certain basic research and clinical questions. It is also a key to the development of a new perspective in biology and medicine. For t...

journal_title：Pediatric clinics of North America

authors： Kirsch IR

更新日期：1988-08-01 00:00:00

abstract：:Herpes simplex encephalitis (HSE) is an uncommon disease, yet 25 to 30 per cent of cases involve children. The initial clinical findings are nonspecific (fever, altered mental status), but most cases evolve to demonstrate focal neurologic signs and symptoms. The CSF is abnormal in over 90 per cent of cases. The EEG, C...

journal_title：Pediatric clinics of North America

authors： Kohl S

更新日期：1988-06-01 00:00:00

abstract：:We have presented the current concepts of gastrointestinal ontogeny--the various factors governing the ontogeny of the gastrointestinal tract and the interaction and intricate relationship between different determinants. It is only through a better understanding of the development of the gut and the various factors af...

journal_title：Pediatric clinics of North America

authors： Lebenthal E,Leung YK

更新日期：1988-04-01 00:00:00

abstract：:Genetic and environmental factors (breast feeding, probably viral infections) play a role in the expression of the disease. Prevalence of GSE in childhood did not substantially decrease in the last 15 years in all European countries, where GSE is still more common in infantile age and presents frequently gastrointesti...

journal_title：Pediatric clinics of North America

authors： Auricchio S,Greco L,Troncone R

更新日期：1988-02-01 00:00:00

abstract：:Conjunctivitis is a common, usually mild, self-limited problem. Pathogens vary at different ages. Conjunctivitis occurs alone or as a manifestation of a systemic infection or a systemic disease. Diagnosis can usually be established by the combination of clinical and laboratory findings. Topical, systemic or combinatio...

journal_title：Pediatric clinics of North America

authors： Fisher MC

更新日期：1987-12-01 00:00:00

abstract：:Blind infants need early and accurate diagnosis. The spectrum of etiologies, from ocular globes and optic nerves to cerebral lesions, is reviewed. A strategy of investigation and principles of management is summarized. ...

journal_title：Pediatric clinics of North America

authors： Buncic JR

更新日期：1987-12-01 00:00:00

abstract：:The application of the principles underlying successful renal transplantation in children has led us to increasing success in achieving our goals, which involve more than simple renal function replacement and include effective growth in stature, skeletal and central nervous system development, as well as social develo...

journal_title：Pediatric clinics of North America

authors： Sheldon CA,McLorie GA,Churchill BM

更新日期：1987-10-01 00:00:00

abstract：:Outpatient encounters form the mainstay of managing type I diabetes mellitus in children and adolescents. Management philosophy rests on the premise that normal physical and emotional growth is attainable and long-term complications minimized by maintenance of metabolic (glycemic) control. Management principles involv...

journal_title：Pediatric clinics of North America

authors： Sperling MA

更新日期：1987-08-01 00:00:00

abstract：:The value of improved intrauterine diagnostic capability is unquestioned; however, as with all new technologic advancements, the problems created by this new diagnostic tool need review. This article examines some of the more critical of these difficulties. ...

journal_title：Pediatric clinics of North America

authors： Grupe WE

更新日期：1987-06-01 00:00:00

abstract：:Pediatricians, as well as other health care professionals, must always consider psychoactive drug use by adolescents as possible causes of general health or emotional problems, such as poor appetite, insomnia, problem behavior, academic underachievement, and loss of energy and motivation. Early diagnosis and intervent...

journal_title：Pediatric clinics of North America

authors： Morrison MA,Smith QT

更新日期：1987-04-01 00:00:00

abstract：:The technology surrounding the treatment of acute renal failure has been traditionally left in the realm of dialysis. The use of peritoneal dialysis for the neonate or small infant and the often difficult use of hemodialysis in larger children and adolescents have been the mainstay of support. Not infrequently, howeve...

journal_title：Pediatric clinics of North America

authors： Paganini EP

更新日期：1987-02-01 00:00:00

abstract：:The stress response in humans commonly includes elevations in plasma concentrations of glucocorticoids, catecholamines, glucagon, growth hormone, aldosterone, and renin, resulting in alterations in the metabolism of glucose and other energy substrates, and in increased sodium and water retention. In severe illness, tr...

journal_title：Pediatric clinics of North America

authors： Weise K,Zaritsky A

更新日期：1987-02-01 00:00:00

abstract：:Spinal deformity is a relatively common disorder, particularly in teenage girls. Early detection is possible by a simple, quick visual inspection that should be a standard part of the routine examination of all preteen and teenage patients. Follow-up observation will reveal those curvatures that are progressive and pe...

journal_title：Pediatric clinics of North America

authors： Bunnell WP

更新日期：1986-12-01 00:00:00

abstract：:Deformities are abnormalities of shape or form caused by abnormal or imbalanced mechanical forces. In prenatal deformation, most infants are intrinsically normal and the deformation results from extrinsic constraining forces. Most prenatal deformities will resolve spontaneously or with the application of counteracting...

journal_title：Pediatric clinics of North America

authors： Dunne KB,Clarren SK

更新日期：1986-12-01 00:00:00

abstract：:There are many conditions that produce chronic arthritis in childhood, including JRA. The pitfalls associated with proper diagnosis involve underrecognition, misrecognition, and overrecognition of symptoms and signs. ...

journal_title：Pediatric clinics of North America

authors： Brewer EJ Jr

更新日期：1986-10-01 00:00:00

abstract：:Prevention of enuresis has not been studied directly. Positive results from a randomized clinical trial evaluating early intervention for children at risk for enuresis would establish the value of prevention and help to promote its practice. Enuresis is not a disease process, and therefore a clinical trial may never b...

journal_title：Pediatric clinics of North America

authors： Friman PC

更新日期：1986-08-01 00:00:00

abstract：:The U.S. Preventive Services Task Force, convened and staffed by the U.S. Public Health Service, is evaluating the scientific basis of various preventive services to develop age- and sex-specific recommendations concerning their appropriate use in clinical settings. Over the course of the next few years, the Task Forc...

journal_title：Pediatric clinics of North America

authors： Mickalide AD

更新日期：1986-08-01 00:00:00

abstract：:This chapter has reviewed the deficiencies in immune defense that place the neonate, particularly the premature infant, at increased risk of invasive bacterial disease. We also have reviewed the literature on the rationale for exchange transfusion, granulocyte transfusion, intravenous immunoglobulin, and fibronectin a...

journal_title：Pediatric clinics of North America

authors： Yoder MC,Polin RA

更新日期：1986-06-01 00:00:00

abstract：:The ingestion of caustic chemical agents, usually accidentally by children, produces a wide range of injuries from minor mouth burns to necrosis of the esophagus and stomach. The type of agent, amount, concentration, and duration of exposure are the determining factors. The treatment for the average burn is fairly wel...

journal_title：Pediatric clinics of North America

authors： Rothstein FC

更新日期：1986-06-01 00:00:00

abstract：:Overdose of a tricyclic antidepressant is a serious and all-too-frequent occurrence. The diagnosis must be considered in known or suspected overdoses, and signs such as a dry axilla, tachycardia, and wide QRS must be specifically sought. Management depends upon support of vital functions and a thorough understanding o...

journal_title：Pediatric clinics of North America

authors： Braden NJ,Jackson JE,Walson PD

更新日期：1986-04-01 00:00:00